Platelet Rich Plasma Therapy in Hair Restoration – PRP Therapy & A-Cell™
we have been performing PRP therapy as a proactive therapeutic option for male and female patients experiencing hair loss. PRP is an exciting non-surgical therapeutic option for patients who require stimulation of hair growth for hair loss conditions.
Recent scientific research and technology provides the medical community with new understandings of wound and tissue healing. As a result of these scientific studies, we know PRP is an all-natural medical procedure performed in physicians offices for hair loss or conditions causing hair thinning. In a recent study published in Dermatologic Surgery, physicians in Korea published data supporting the clinical application of PRP in hair restoration.
HOW DOES PRP WORK?
Human blood contains mesenchymal stem cells and autologous blood products that contain essential and specific growth factors that assist in tissue regeneration and healing. Published medical literature from Europe and the United States confirms the safety and use of PRP therapy. PRP therapy has established itself to be effective as a medical treatment modality in the specialty fields of oral surgery, neurosurgery, plastic and cosmetic surgery, sports medicine and orthopedics. It has been used extensively in these specialties for the last two decades with generally positive outcomes and success. In the field of hair restoration, existing evidence demonstrates PRP therapy as a promising treatment option to promote hair growth.
While PRP is in the early stages of scientific research in hair restoration, PRP is not meant to replace current FDA approved therapies such as DHT blockers and Minoxidil. but it is a promising non-surgical therapeutic option for those patients with hair loss.
HOW DO YOU PERFORM THE PROCEDURE?
Blood is drawn in our office as though you are having routine blood testing at your primary care physician’s office. The blood is spun in a centrifuge and the PRP is separated and removed from the rest of the blood.
The PRP is taken from your body and is specially prepared by spinning down the blood cells to a high concentration. We are proud to use the state of the art AutoloGel system technology, designed by Cytomedix. After centrifugation, the platelets and other vital growth proteins raise to the top of the tube. Under a topical anesthesia, a special micro needling roller device is used to stimulate the dermis of the scalp. This micro needling stimulation causes microtrauma to the dermis that induces other healing and growth repair cells into action. The highly concentrated platelet rich plasma (PRP) is then injected into the scalp and topically.
The PRP contains many growth factors that stimulate the hair follicle’s growth. PRP can be used preoperatively, intraoperatively, or post operatively. Some patient’s chose to have PRP performed every three (3) to four (4) months as early data suggests regular or semiannual PRP treatments can stimulate hair growth.
THE SCIENCE OF PRP
PRP contains special cells called Platelets, that can cause growth of the hair follicles by theoretically stimulating the stem cells located in the Dermal Papilla as well as other structures of the hair follicle These special Platelet cells promotes healing, accelerates the rate and degree of tissue healing and regeneration, response of the body to injury, and formation of new cellular growth. The primary purpose of using PRP in hair restoration is to stimulate inactive or newly implanted hair follicles into an active growth phase.
Inside the Platelets are many intracellular structures such as glycogen, lysosomes and alpha granules. These granules within the PRP contain clotting and growth factors that are eventually released during the healing and repair process.
PRP specific cells that causes hair growth include:
- Platelet-Derived Growth Factor (PDGF)—promotes blood vessel growth, cell replication, skin formation;
- Transforming Growth-Factor-Beta (TGF-b)—promotes growth of matrix between cells, bone metabolism;
- Vascular Endothelial Growth Factor (VEGF)—promotes blood vessel formation;
- Epidermal Growth Factor (EGF)—promotes cell growth and differentiation, blood vessel formation, collagen formation;
- Fibroblast Growth Factor-2 (FGF-2)—promotes growth of specialized cells and blood vessel formation; and,
- Insulin Like Growth Factor – (IGF)—a regulator of normal physiology in nearly every type of cell in the body.
DOES PRP WORK?
While individual results vary and no guarantees of success can be made, preliminary studies indicate many patients respond to PRP therapy. Some hair restoration physicians apply PRP to the scalp for those patients who are not surgical candidates every three (3) to four (4) months. Other protocols will use PRP before or during surgery to insure graft survivability.
PRP is an emerging non surgical based therapy for natural stimulation for thinning hair. Larger clinical studies are pending but the current medical literature contains numerous positive results. Although a few controlled studies exist, anecdotal and case reports are the primary sources reflecting success with PRP therapy.
WHO SHOULD NOT HAVE PRP TREATMENT?
Patients with history of heavy smoking, drug and alcohol use. Medical diagnosies such as platelet dysfunction syndromes, thrombocytopenias, hypofibrinogenaemia, hemodynamic instability, sepsis, acute and chronic Infections, chronic liver disease, anti-coagulation therapy, chronic skin diseases or cancer, metabolic and systemic disorders.
IS PRP FOR ME?
PRP has been used successfully in other medical and surgical disciplines for many years. The decision to use PRP is a personal decision and should be made after careful research, consideration and consultation with a physician. PRP is safe and natural because the procedure concentrates the good cells from your own body directly back into the area where it is needed. There is absolutely no chance of getting a blood infection from another human being. PRP involves using your own cells and it will not be rejected by your immune system.
Clinical trials are not complete and medical data is not yet published to determine the effectiveness of PRP therapy in hair restoration. PRP should not be considered a “cure” for hair loss and no guarantee can be made about its individual effectiveness. No claim of PRP efficacy in promoting hair growth can be made because there is no FDA approval that would allow such claims to be made.
CAN I USE OTHER MEDICAL THERAPIES CONCURRENTLY?
Absolutely. In fact, we encourage it and prescribe PRP therapy as a compliment to a nonsurgical approach for those patients who are not eligible for surgery or who want to delay hair restoration surgery. As a non-surgical treatment option, we recommend PRP therapy along with Minoxidil and DHT blockers or for those patients who can not tolerate or have side effects with these medications.
In summary, PRP therapy offers a promising alternative for natural hair growth for those patients who are not candidates for surgery. It also is a beneficial therapy for surgical patients who want PRP therapy as a complimentary procedure at the same time hair restoration surgery with either automated FUE or the STRIP procedure.
Whether you are looking for additional hair stimulation, or are looking to have hair surgery with the addition of PRP, OC Hair Restoration center is able to meet your needs. Although results will vary from patient to patients, PRP as a non-surgical option offers patients with miniaturization and hair thinning improvement in hair caliber and thickness.
Chances of result with Mesotherapy are 90-92% as apposed to commonly used Minoxidil (Rogaine) only 50%.
Most forms of hair loss are caused by
- hormone imbalances in and around the hair follicle
- a lack of the right nutrients
- reduced blood circulation
Our mesotherapy treatment tackles exactly those 3 problems which results in a stimulation of natural hair growth and immediate stopping of hair loss.
What is Mesotherapy?
Mesotherapy is a non-invasive technique based on superficial microinjections, just below the epidermis, into the target tissues. The term «meso» is derived from the mesoderm or middle layer of the skin (approx. 1 mm deep). Mesotherapy is a treatment that stimulates the mesoderm, which relieves a wide variety of symptoms and ailments.
The solution injected can contain a wide range of minerals, vitamins, amino acids, nucleic acids and co-enzymes that can be tailored to each patient’s individual needs.
Mesotherapy for hair loss is used with great success in Europe and the United States. The treatment is virtually painless and safe when done professionally. There is no dressing or local anaesthesia required. After the treatment you can just go back to work.
Today we know that Mesotherapy is as effective or more effective than tablets in hair rejuvenation and restoration.
Mesotherapy brings just the right materials to the exact place where it is needed (around the hair follicle) so that
- the hair follicle can grow and survive,
- the excess of DHT (dihydrotestosterone) is neutralised and
- the blood circulation is stimulated.
View more Before & After images >
History of Mesotherapy
In 1952 Dr Michel Pistor treated the cobbler for an asthma attack with procaine, in his village of Bray et Lu. This treatment had a limited effect on the underlying disease although the patient, who had been deaf for many years, was able to hear the village bells ring again. He then thought of continuing the procaine treatment but administered next to the ear with positive results. It was from this finding that he continued a never ending quest to treat the disease from as close a point as possible. And according to his saying “a little, not very often, in the right spot”.
In 1964 the French Society of Mesotherapy was founded in Paris, with 16 members and The French Academy of Medicine recognized Mesotherapy as a Specialty of Medicine in 1987.
Popular throughout European countries and South America, Mesotherapy is practiced by approximately 40.000 physicians worldwide.
Mechanism of action of Mesotherapy
Mesotherapy employs both the physical (mechanical) and the chemical stimulation. Small doses of different medications are administered in specific areas depending on the condition being treated. They act like a medicinal bullet that is delivered directly to a target in the body.
Mechanical: The needle is creating micro perforations that induce a healing process. The posttraumatic response of the organism is to produce collagen and elastin – two of the key building blocks of skin. As there is no removal or “real” damage to existing collagen, the new formation of it simply adds to existing levels.
Chemical: The injected active ingredients will stimulate the organism. For instance, if the circulation is poor, a vasodilator is used ( ex. coumarin); if excessive inflammation is present, an anti-inflammatory medication is used (ex. organic silicon). The quality of the product, its composition regarding the indication to treat is of first importance.
Mesotherapy in hair loss
An effective time-release delivery system that can improve blood circulation, reduce inflammation, neutralize excess DHT, stimulate collagen, increase follicle size to stop hair loss and stimulate hair growth.
Active Ingredients Acetyl tetrapeptide-3 & Biochanin A
Acetyl tetrapeptide-3: alternative to Minoxidil
Reduces the inflammation process stops hair loss and stimulates the hair growth (comparative study to minoxidil) modulates DHT, stimulates the extra cellular matrix and anchoring proteins. Acetyl tetrapeptide-3 stimulates tissue remodeling and has a direct effect on the hair follicle. The remodeling signal will increase the size of hair follicle for better hair anchoring and vitality.
Biochanin A is a powerful isoflavone, derived from red clover. It is a natural organic compound in the class of phytochemicals known as flavonoids. Red clover was traditionally used to treat asthma, cancer and inflammatory skin disorders such as eczema & psoriasis. Biochanin A modulates the conversion of testosterone to DHT in androgenic alopecia.
All this results in a stimulation of natural hair growth.
Chances of result with Mesotherapy are 90-92% as apposed to Minoxidil (Rogaine) only 50%.
Most forms of hair loss are caused by hormone imbalances in and around the hair follicle, a lack of the right nutrients and reduced blood circulation.
The treatment itself takes between 10 and 30 minutes depending on the extension of the area being treated.
Usually a minimum of 10 sessions is required to stimulate hair growth. We recommend starting with an intensive course of treatments every 2 weeks for the first 2-3 months. The frequency then gradually decreases and the results of hair rejuvenation become evident already after 2-3 months. In order to keep the results maintenance treatments are needed generally once every 2 to 3 months.
Stem Cell Hair Loss
Why Stem Cells?
Stem cells are tiny progenitor cells found in our body that can divide (through mitosis) and change (differentiate) into various cell types. All cells in our body are constantly dividing where new cells are formed, then cells age and die. It is a natural physiologic process of programmed cell death and is known as Apoptosis. Your stem cells are your body’s natural healing cells and can act as your repair system in your body by replenishing adult tissues. They are the source of all these cells that have died.
There are two broad types of stem cells: embryonic stem cells, which are isolated from the inner cell mass of blastocyst (early stage of embryo), and non-embryonic or adult stem cells. It is also referred to as mesenchymal stem cells MSCs and is found in various tissues. There are three accessible sources of autologous adult stem cells in humans:
- Bone marrow, which requires extraction by drilling into the bone (typically the femur or iliac crest).
- Blood, which requires extraction through pheresis, wherein blood is drawn from the donor (similar to a blood donation), passed through a machine that extracts the stem cells and returns other portions of the blood to the donor.
- Adipose tissue (Fat cells), which requires extraction by liposuction.
Stem cells can also be taken from umbilical cord blood just after birth. Of all stem cell types, autologous harvesting (cells are obtained from one’s own body) from Adipose tissue (Fat cells) involves the least risk. Adipose tissue (fat cells) is one of the richest sources of MSCs. When compared to bone marrow, there are more than 500 times more stem cells in 1 gram of fat when compared to 1 gram of aspirated bone marrow.
Soleen Lebanese beauty center has the technology to extract stem cells from your fat cells. Under investigational protocols, these cells can be deployed to treat a number of degenerative conditions and diseases. NESCTC in collaboration with Soleen Lebanese beauty center is pioneering deploying stem cells to treat thinning hair and hair loss.
Hair follicles also contain stem cells, and some researchers predict research on these follicle stem cells may lead to successes in treating baldness through an activation of the stem cells progenitor cells. This therapy is expected to work by activating already existing stem cells on the scalp. Later therapy may be able to simply signal follicle stem cells to give off chemical signals to nearby follicle cells which have shrunk during the aging process, which in turn respond to these signals by regenerating and once again making healthy hair. Most recently, Dr. Aeron Potter of the University of California has claimed that stem-cell therapy led to a significant and visible improvement in follicular hair growth.
How do you grow hair follicles from stem cells?
Mesenchymal stem cells or MSCs are multipotent stromal cells that can differentitate into a variety of cell types including: osteoblasts (bone cells), chondrocytes (cartilage), connective tissues and adipocytes (fat cells). Hair follicle papilla, which is a large structure at the base of the hair follicle bulb, is made up mainly of connective tissue and a capillary loop. (See hair follicle illustration). Since it is mainly connective tissue, mesenchymal stem cells could play a role in the repair and regenesis of the hair follicle papilla. Another point to consider is that the hair follicle develops mainly from the dermis and is mesodermal in origin. In Mesenchymal stem cells are also mesodermal in origin. Furthermore, there is tight ectodermal and mesodermal interaction involve in hair follicle development.
Discoveries in recent years have suggested that adult stem cells might have the ability to differentiate into cell types from different germ layers. For instance, neural stem cells from the brain, which are derived from ectoderm, can differentiate into ectoderm, mesoderm, and endoderm. Stem cells from the bone marrow, which is derived from mesoderm, can differentiate into liver, lung, GI tract and skin, which are derived from endoderm and mesoderm. This phenomenon is referred to as stem cell transdifferentiation or plasticity.
Soleen Lebanese beauty center , an affiliate of the Cell Surgical Network , uses adipose derived stem cells, commonly known as Stromal Vascular Fraction (SVF) and non embryonic/adult mesenchymal stem cells, for deployment & clinical research.. Early stem cell research has traditionally been associated with the controversial use of embryonic stem cells. The new focus is on non-embryonic adult mesenchymal stem cells, which are found in a person’s own blood, bone marrow, and fat. Most stem cell treatment centers in the world are currently using stem cells derived from bone marrow.
A recent technological breakthrough enables us to now use adipose (fat) derived stem cells. The procedure entails performing a mini-liposuction (around 50 mL of fat tissue) from the lower abdomen or from the belly under local anesthesia. Mesenchymal stem cells are then extracted from the adipose tissues, which are then incubated. The resulting lipoaspirate are either injected directly into areas concerned or injected directly intravenously.
Autologous stem cells from a person’s own fat are easy to harvest safely under local anesthesia and are abundant in quantities which are up to 500 times those seen in bone marrow. Clinical success and favorable outcomes appear to be related directly to the quantity of stem cells deployed. Once these adipose derived stem cells are administered back in to the patient, they have the potential to repair human tissue by forming new cells of mesenchymal origin, such as connective tissues, cartilage, bone, ligaments, tendons, hair follicles, nerve, fat, muscle, blood vessels, and certain internal organs.